By H. Ballentine Carter M.D., Donald S. Coffey Ph.D. (auth.), Donald S. Coffey, Martin I. Resnick, F. Andrew Dorr, James P. Karr (eds.)
These complaints emanate from the second one Prouts Neck convention on prostate melanoma hung on October 17-19, 1986, the subject of which used to be deal with ment, with concentrate on present concerns and destiny study that's had to resolution serious questions with regards to optimum administration of a few of the levels of prostate melanoma. the target used to be to bare the main the most important difficulties impeding growth and to crystallize the mixed multidisci plinary enter generated via the convention into concentrated ideas or concepts for presentation to the nationwide melanoma Institute (NCI) , with the last word reason of focusing on learn to deal with the concern matters pointed out. In organizing the workshop, each attempt used to be made to keep up a multidisciplinary stability between nationally popular experts on prostate melanoma. hence, major surgeons, radiation and clinical onco logists and biostatisticians have been in equivalent presence. whereas there have been lively exchanges with cautious scrutiny and critique of all info pre sented, there has been a typical trust that the problem of prostate melanoma will be most sensible approached during this multidisciplinary Organ Systems-oriented type. through the process the convention, it turned obvious to all current that significant nomenclature and procedural boundaries have made it regularly tough, and often very unlikely, to match result of medical research.
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Additional info for A Multidisciplinary Analysis of Controversies in the Management of Prostate Cancer
Parfitt studied Stage Al patients who subsequently underwent either radical prostatectomy or repeat transurethral resection (23). He reported that patients with high 42 grade tumor had a greater incidence of diffuse involvement by carcinoma within their subsequent resections, concluding that high grade tumors should be considered Stage A2 . Though many authors have recognized these findings and have excluded high grade tumors from their Stage Al (2,3,24), many reports within the literature include high grade tumors within their study of Stage Al creating much difficulty in interpretation of their data (4,16,21,22).
In direct contrast, the incidence of clinically manifest prostatic cancer varies widely internationally. 3 for American and Japanese men, respectively (30), even though the incidence rates for microscopic prostatic cancer is approximately 20 percent for both of these groups of men (31,32). These results demonstrate that only a very small fraction of microscopic prostatic cancers progress during the lifetime of the host to produce clinical disease. These observations demonstrate that: 1) the factors(s) involved in the development of microscopic prostatic cancer are present universally with an equally high frequency in all geographic male populations, and 2) the progression of microscopic cancer to a clinical disease must involve additional malignant steps brought about by factor(s) which are not present with an equal frequency in all male populations.
Dis. 26:623-646, 1973. 23 9. 10. 11. 12. 13. 14. 15. F. J. Cancer mortality among Chinese Americans, 1950-69 J. Nat. Cancer Inst. 52:659-665, 1974. Akazaki, K. N. Comparative study of latent carcinoma of the prostate among Japanese in Japan and Hawaii. J. Nat. Cancer Inst. 50:1137-1144, 1973. A. and Correa, P. Geographic pathology of latent prostatic carcinoma. Int. J. Cancer 29:611-616, 1982. J. M. Fenoglio-Preiser, M. Wolff and F. , Field and Wood, Philadelphia, 1987. Kastendieck, H. Correlations between atypical primary hyperplasia and carcinoma of the prostate: A histologic study of 180 total prostatectomies.
A Multidisciplinary Analysis of Controversies in the Management of Prostate Cancer by H. Ballentine Carter M.D., Donald S. Coffey Ph.D. (auth.), Donald S. Coffey, Martin I. Resnick, F. Andrew Dorr, James P. Karr (eds.)